Endocrine Abstracts

Purpose: To detect persistent/recurrent disease of medullary thyroid carcinoma (MTC) after initial surgery is important. The Tumor-Node-Metastasis (TNM) staging system is useful for predicting disease-specific mortality, but it is static and does not include postoperative serum calcitonin levels. We focused on the clinical usefulness of dynamic risk stratification (DRS) using the best response to initial therapy in patients with MTC.Methods: A total of 1...

Background: Optimal production of cellular energy and metabolites in mitochondria is one of the most important factors in endocrine organs that accomplish the momentary adaptation to ligand stimulation, such as insulin secretion and aldosterone biosynthesis. Although it has been suggested that thyroid gland function is also largely dependent on mitochondrial function, functional behavior of thyroid gland on compromised mitochondrial function remained to be identified. In this ...

Although non-alcoholic fatty liver disease (NAFLD) patients are rapidly growing, there is not optimal therapy to improve NAFLD. NAFLD is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activator thiazolidinediones (TZD) is an insulin sensitizer, and have been focused as the drug for NAFLD. However, the TZD remain debate as drug of choice on NAFLD because of its conflicting results on the hepatic steatosis and fibrosis. Lobegli...

Background: Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management for these low risk DTCs. The aim was to validate a new dynamic risk stratification (DRS) system for prediction of structural recurrent/persistent disease in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy.Methods: This historical cohort study included 357 pat...